Resolution of Cystoid Macular Edema Secondary to Radiotherapy following Topical Nepafenac Treatment

Objective: To report on the use of topical nepafenac in the treatment of cystoid macular edema (CME) secondary to radiation therapy for choroidal metastasis. Method: Case report with presentation of spectral domain optical coherence tomography (SD-OCT) findings before and after topical nepafenac therapy. Results: A 42-year-old lady with a history of breast carcinoma presented with left eye blurring of vision due to left eye choroidal metastasis. Radiation therapy was performed on the left eye for choroidal metastasis and the choroidal metastasis completely regressed. Two months after radiation therapy, the patient developed reduced vision due to macular edema and SD-OCT demonstrated CME with macular thickening. Topical nepafenac therapy for 1 month resulted in complete resolution of the CME and her vision improved from 20/70 to 20/25. There was no evidence of recurrence of CME in 8 months after cessation of nepafenac therapy. Conclusion: Topical nepafenac appeared to be a useful treatment option for CME secondary to radiation therapy.